Bioresources, University of Kashmir

An alteration in the metabolism of cancer cells is considered to be fundamentally connected to the transformation of a normal cell to a cancerous cell. Unlike the normal cells, cancer cells exhibit glycolysis even in the presence of oxygen. This “aerobic glycolysis” or Warburg effect may be the result of abnormalities like mitochondrial damage, adaptation to hypoxia within tumors, oncogenic stimuli and particularly over expression of glycolytic enzymes which in turn support cancer cell survival and proliferation. In cancer cells lipogenesis, like glycolysis, is also regulated by oncogenic pathways and is considered to be responsible for tumor survival, initiation, progression and aggressiveness. Targeting PI3K, which is the most proximal component of the glycolytic pathway, is a more suitable approach than targeting any of the more distal components like Akt and mTOR. This is because inhibiting the PI3K component provides a broader and earlier inhibition of all the signals that are downstream to it like Rac and mTOR. Additionally, PI3K inhibition overcomes the possibility of increased proliferation which might be triggered due to the activation of the pathway by a feedback loop and/or crosstalk with Ras/Raf/Mek/Erk pathway. So our target is to screen and evaluate of PI3K-Akt-mTOR-CDK targets by dual inhibition cum combinatorial approach.
Macrophages are a fundamental part of the innate defense mechanisms, which can promote specific immunity by inducing T cell recruitment and activation. Despite this, their presence within the tumour microenvironment has been associated with enhanced tumour progression and shown to promote cancer cell growth and spread, angiogenesis and immunosuppression. This paradoxical role of macrophages in cancer finds an explanation in their functional plasticity that may result in the polarized expression of either pro- or anti-tumoural functions. Generally, in the presence of different signals, macrophages may undergo classical M1 activation (stimulated by TLR ligands and IFN-γ) or alternative M2 activation (stimulated by IL-4/IL-13). M1 phenotype is characterized by the expression of high levels of proinflammatory cytokines, high production of reactive nitrogen and oxygen intermediates, promotion of Th1 response, and strong microbicidal and tumoricidal activity. In contrast, M2 macrophages are considered to be involved in parasite containment and promotion of tissue remodeling and tumor progression and to have immunoregulatory functions. so our target is to explore the role of altered tumor microenvironment on angiogenesis, metastasis and tumor inhibition.
Tuberculosis (TB) has been the subject of control programs since prehistoric times, but still it remains a serious challenge to public health programmes. TB remains an enormous health and economic problem not only in developing regions but also in high-income countries due to emergence of drug resistant TB (DR-TB) and TB-HIV co-infection. Drug resistance is a costly consequence of pathogen’s evolution and a major concern in public health. India has the highest TB burden among all the countries in the world and accounts for one fourth of the global TB burden. Global TB Report 2016 confirms that India has the highest burden of both drug susceptible and drug resistant TB throughout the world. Improving TB control requires a better understanding of impact of the environment on the interaction between the pathogen and its host i.e. population based examination of prevalence of drug resistance, their susceptibility patterns, their genetic setup etc. study will be the population-based to find the molecular basis of Drug and MDR-TB in Kashmir and its findings will lead to a better understanding of the emergence of drug and multi-drug resistance at population level. Those in turn will provide the type of data needed to improve local and national TB control programs also. Further our group will focus on to elucidate the molecular mechanism involved in drug and multidrug resistance in bacterial pathogens like mycobacteria and Slamonella.

MOOC Courses Developed with MHRD Ministry Govt of India

1. MOOC on Immunology

https://onlinecourses.swayam2.ac.in/cec20_bt05/preview

2. MOOC on Endocrinology

https://onlinecourses.swayam2.ac.in/cec20_bt21/preview

3. MOOC on Human Genetics

https://onlinecourses.swayam2.ac.in/cec23_bt05/preview

4. MOOC on Human Population Genetics

https://onlinecourses.swayam2.ac.in/cec23_bt04/preview

B. MOOC Course successfully Completed with Certification from NPTEL and UGC

1. Introduction to Research by NPTEL (Roll No. NPTEL20GE04S1316278) IIT Madras

https://onlinecourses.nptel.ac.in/noc20_ge04/preview

2. Human Genetics by CEC-UGC MHRD University of Mysore

https://onlinecourses.swayam2.ac.in/cec20_bt17/preview

3. Immunology by NPTEL MHRD IIT Kharagpur

https://onlinecourses.nptel.ac.in/noc20_bt43/preview

4. Cancer Fundamentals by AICTE MHRD University of Delhi

https://onlinecourses.swayam2.ac.in/aic20_ge02/preview

C. MOOC Courses Ongoing through SWYAM

1. Enzymology by CEC-UGC MHRD

https://onlinecourses.swayam2.ac.in/cec20_bt20/preview

2. Intellectual Property (IP) by CEC-UGC-MHRD

https://onlinecourses.swayam2.ac.in/cec20_hs18/preview

Research Grants:

S. No/ File No. of Project	Title of the project	Funding Agency
TAR/2018/001213 Dated: 05-11-2018	Elucidation of Molecular Basis of Drug and Multidrug Tuberculosis Resistance of Mycobacterium tuberculosis in Kashmir Valley	SERB-DST-India
P-3 SATCAS-03/2013/MU Dated: 06-10-2013	Studies on the TNF receptor modulation and its impact on the cellular survival by some natural herbs in OGD model of stroke	SATCAS-MU-KSA
P-18 BHSRC-18/2014/MU Dated: 21-08-2014	Neuroprotective effect of E. densa in cellular survival after cerebral ischemia in oxidative and inflammatory in vitro models of Stroke	BHSRC-MU-KSA
JKST&IC/SRE/885-87 Dated: 27-10-2021	Targeting drug resistant cancer stem cells by combinational delivery of Paclitaxel and Quercetin/Zerumbone in breast cancer	J&K S&T-IC

Lab Members of Dr. Manzoor
Ph. D students
S.N	Name	Awards
1	Mr. Umar Mehraj Sheikh	JRF-CSIR
2	Miss Mehak Majeed	JRF-CSIR
3	Mr. Bashir Ahmad Sheikh	NET-CSIR, SET-JK
4	Mr Basharat Ahmad Bhat	M Phil
5	Miss Hina Qayoom
6	Miss Hafsa Qadri
7	Mr. Wajahat Rashid Mir	JRF-NET MANAF

M. Sc 4^th Semester Projects/Dissertations Carried out under the supervision of Dr. Manzoor Ahmad Mir in the Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar
S. No.	Name of the Candidate	Enrolment No.	Reg No. of Candidate	Year of completion	Title of the Dissertation/Project
01	Miss Najwa Shabir	15060119009	61697-W-2012	2018	Quality Analysis of anti-epileptic drugs available in local market using HPLC
02	Mr. Adil Manzoor	15060119005	26240-SJ-2012	2018	Quality Analysis of anti-epileptic drugs available in local market using HPLC
03	Mr Gazie Shaban	15060119018	28238-IC-2010	2018	Quality Analysis of anti-epileptic drugs available in local market using HPLC
04.	Miss Daurdana Bano	16060119014	47109-S-2012	2018	Determination of Vancomycin in Pharmaceuticalformulations available in local market using HPLC
05	Miss Aqiba Jahan	16060119012	91171-W-2012	2018	Determination of Vancomycin in Pharmaceuticalformulations available in local market using HPLC
06	Miss Snober Ali	16060119011	64343-W-2013	2018	Determination of Vancomycin in Pharmaceuticalformulations available in local market using HPLC
07	Miss Shazia Shafi	18060119010	64380-W-2013	2020	Validation of CDKI expressing and its prognostic significance in Breast Cancer using integratedbioinformatics analysis
08	Miss Shariqa Jan	18060119011	61609-W-2012	2020	Elucidation of Prognostic and functional role BIRC5in Breast Cancer using Bioinformatics analysis
09	Miss Pz Farhana Anjum	18060119008	2689-DRA-2012	2020	Bioinformatics analysis showing prognosticsignificance of TOP2A in Breast Cancer
10	Mr. Gh. Nabi	18060119002	16728-KC-2014	2020	Ethnobotanical approach for the Management of seasonal respiratory allergenic disorders
11	Miss Iqra Nabi	18060119004	67028-W-2014	2020	Ethnobotanical approach for the Management of seasonal respiratory allergenic disorders
12	Miss Seerat Hussain	18060119005	1475-SC-2015	2020	Ethnobotanical approach for the Management of seasonal respiratory allergenic disorders
13	Miss Saleeqa Yaseen	18060119003	14060-SC-2015	2020	Candida and pathogenesis in human hosts: A systemic Review
14	Miss Ulfat Jan	18060119006	21014-G-2012	2020	Candida and pathogenesis in human hosts: A systemic Review
15	Mr Muhammad Usman	18060119007	12896-SC-2014	2020	Candida and pathogenesis in human hosts: A systemic Review
16	Miss Heena Zehra	19060119018	68634-W-2015	2021	Comprehensive analysis of MAP kinase signalling pathway in Breast Cancer: An integrated Insilco Study
17	Miss Shreen Rashid	19060119016	68561-W-2015	2021	Glucose Metabolism in Breast Cancer :An integrated In-Silico Analysis
18	Miss Aanisa Makhdoomi	19060119003	42255-SP-2015	2021	Fatty Acid Metabolism in Breast Cancer : An integrated In-Silico Analysis
19	Miss Nighat Khaliq	19060119002	68573-W-2015	2021	A comprehensive Bioinformatic Analysis of Notch Pathway in Breast Cancer
20	Mr Mubashir Imtiyaz	19060119004	42254-SP-2015	2021	Phytochemical Screening and Medicinal activity of versatile Medicinal plant Podophyllum hexandrum
21	Miss Aamina Mohi u Din	19060119005	35639-BC-2015	2021	Phytochemical Screening and Medicinal activity of versatile Medicinal plant Podophyllum hexandrum
22	Sadaf Aadina	19060119012	14009-SC-2015	2021	Phytochemical Screening and Medicinal activity of versatile Medicinal plant Podophyllum hexandrum
23	Mr. Aashiq Hussain War	19060119010	1660-PGD-2019	2021	Covid-19 Pandemic and its impact on patients with cancer
24	Mr. Zia ul Mumin Raina	19060119011	3384-IC-2013	2021	Covid-19 Pandemic and its impact on patients with cancer
25	Mr. Aabida Gul	19060119014	11817-GBL-2015	2021	Covid-19 Pandemic and its impact on patients with cancer

Publications:

List of Representative International Books Published in Thompson Reuters (ISI) Web of Science

Manzoor A Mir (2015) Developing Costimulatory Molecules for Immunotherapy of Diseases Elsevier Publishers USA ISBN (Print) ISBN (ebook) 9780128026755: 978-0-12-80-2585-7 26th May 2015, Pp 322 URL: http://store.elsevier.com/Developing-Costimulatory-Molecules-forImmunotherapy- of Diseases /Manzoor-Ahmad-Mir/isbn-9780128026755/
Manzoor A. Mir (2020). Basics and Fundamentals of Immunology (Text Book), ISBN: 978-1-53616-639-2 Nova Biomedical Science Publishers USA (ISI-Web of Science) June 2019 Pg. No.:1-334 https://novapublishers.com/shop/basics-and-fundamentals-of-immunology/
Manzoor A. Mir (2019). Plant Metabolites in the Treatment of Cancer and cerebrovascular Diseases ISBN: 978-1-63278-073-7, DOI: 10.4172/978-1-63278-073-7, OMICS International Publishers UK. July, 2019 Pg. No.:1-176
Manzoor A. Mir (2020). Immunoglobulins, Magic Bullets and Therapeutic Antibodies (Text Book), ISBN: 978-1-53616-903-4, Nova Science Publishers Newyork USA (ISI-Web of Science) October 2019 Pg. No.:1-365 https://novapublishers.com/shop/immunoglobulins-magic-bullets-and-therapeutic-antibodies/
Manzoor A. Mir (2020). Cytokines and their Therapeutic potential (Text Book), ISBN: 978-1-53617-017-7 , Nova Science Publishers Newyork USA (ISI-Web of Science) November 2019 Pg. No.:1-285 https://novapublishers.com/shop/cytokines-and-their-therapeutic-potential/
Manzoor A Mir and Raid S Albaradie (2015) Natural Herbs in the Prevention and treatment of Stroke Nova Science Publishers Inc USA. ISBN: 978-1-63483-555-8. 2015 Pp;250
Manzoor A. Mir, Raid S Albaradie and Malik D Alhusainwi (2014) Recent Advances in Stroke Therapeutics. ISBN: 978-1-62808-521-4 (P), e-book ISBN: 978-1-63117-754-5 April 2014 Nova Biomed. Science Inc. Publishers USA. April, 2014. Pp 1-252. Publication URL: https://www.novapublishers.com/catalog/product_info.php?products_id=49332&osCsid=4 c7e974c9cae59f2482a5ede69ff5af5
Manzoor A Mir, Raid S Albaradie and Abdul R Alharbi Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas: 2013 ISBN:978-1-62808-519-8 Nova URL:https://www.novapublishers.com/catalog/productinfo.php?products_id=46107&osCsid=4c7e974c9cae59f2482a5ede69ff5af5
Manzoor A Mir, The fundamentals of Hypersensitivities and Allergies: (2019). Nova Biomedical Science Publishers New York USA, ISBN: 978-1-53617-012-2, Pp 1-185.
Manzoor A. Mir, Raid S Albaradie and Javed N. Agrewala. (2013) Cancer and Infectious Diseases: Modern Approaches of Treatment ISBN No. 978-3-659-39067-8 Lam. Pub. Germany. Publication URL: http://www.amazon.com/Cancer-Infectious-Diseases- approaches-treatment/dp /3659390674
Manzoor A Mir (2019) Natural Medicine in Cerebrovascular Diseases, ISBN No. 9789385497940, Book Title : Natural Medicine in Cerebrovascular Diseases, Edition: First Publisher: Ariana/Dilpreet Publishers New Delhi India, pp.1-127

List of Representative Book Chapters published in Thompson Reuters ISI Web of Science

Manzoor A Mir (2015) Concept of Reverse Costimulation and Its Role in Diseases, ISBN No. 978-0-12-802585-7, DOI: 10.1016/B978-0-12-802585-7.00002-9, Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First, Chapter: 2, Publisher: Elsevier Publishers USA, pp.45-81URL: https://www.sciencedirect.com/science/article/pii/B9780128025857000029
Manzoor A Mir (2015) T-Cell Costimulation and Its Applications in Diseases, ISBN No. 978-0-12-802585-7,DOI: 10.1016/B978-0-12-802585-7.00006-6,Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First Edition, Chapter: 6, Publisher: Elsevier Publishers USA, pp.255-292 URL: https://www.sciencedirect.com/science/article/pii/B9780128025857000054
Manzoor A Mir (2015) Costimulation Immunotherapy in Allergies and Asthma, ISBN No. 978-0-12-802585-7, DOI: 10.1016/B978-0-12-802585-7.00004-2, Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First Edition, Chapter: 4, Publisher: Elsevier PublishersUSA,pp.131-184URL: https://www.sciencedirect.com/science/article/pii/B9780128025857000042
Manzoor A Mir (2015) Introduction to Costimulation and Costimulatory Molecules, ISBN No. 978-0-12-802585-7, DOI: 10.1016/B978-0-12-802585-7.00001-7, Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First, Chapter: 1, Publisher: Elsevier Publishers USA, pp.1-43 URL:https://www.sciencedirect.com/science/article/pii/B9780128025857000017
Manzoor A Mir (2015) Costimulation Immunotherapy in Infectious Diseases, ISBN No. 978-0-12-802585-7,DOI: 10.1016/B978-0-12-802585-7.00003-0,Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First, Chapter: 3, Publisher: Elsevier Publishers USA, pp.83-129 URL: https://www.sciencedirect.com/science/article/pii/B9780128025857000030
Manzoor A Mir (2015) Costimulation in Lymphomas and Cancer, ISBN No. 978-0- 12-802585-7, DOI: 10.1016/B978-0-12-802585-7.00005-4, Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First, Chapter: 5, Publisher: Elsevier Publishers USA, pp.185-254URL: https://www.sciencedirect.com/science/article/pii/B9780128025857000054
Manzoor A Mir (2015) An Introduction to Cerebrovascular Diseases ISBN: 978-1- 63483-555-8, Book Title: Role of Natural Herbs in Stroke Prevention and Treatment Chapter-1 Publisher: NOVA Science Publishers USA .pp.1-36. URL: http://www.novapublishers.org/catalog/product_info.php?products_id=55796
Manzoor A Mir (2015) Immunobiology of Stroke ISBN: 978-1-63483-555-8, Book Title: Role of Natural Herbs in Stroke Prevention and Treatment Chapter-2 Publisher: NOVA Science Publishers USA .pp.37-106. URL: http://www.novapublishers.org/catalog/product_info.php?products_id=55796
Manzoor A Mir (2015) Natural Herbs, Human Brain and Neuroprotection ISBN: 978- 1-63483-555-8, Book Title: Role of Natural Herbs in Stroke Prevention and Treatment Chapter-3 Publisher: NOVA Science Publishers USA. pp. 107-168. URL: http://www.novapublishers.org/catalog/product_info.php?products_id=55796
Manzoor A Mir (2015) Natural Herbs in Stroke prevention and Treatment ISBN: 978-1-63483-555-8, Book Title: Role of Natural Herbs in Stroke Prevention and Treatment Chapter-4 Publisher: NOVA Science Publishers USA. pp. 169-204. URL: http://www.novapublishers.org/catalog/product_info.php?products_id=55796
Manzoor A Mir (2015) Polyphenols from Natural Herbs in Neuroprotection ISBN: 978-1-63483-555-8, Book Title: Role of Natural Herbs in Stroke Prevention and Treatment Chapter-5 Publisher: NOVA Science Publishers USA. pp. 205-238. URL:http://www.novapublishers.org/catalog/product_info.php?products_id=55796
Manzoor A Mir Raid S Albaradie and Malik Alhasanavi (2014) Immune System and Strokes ISBN: 978-1-63117-754-5 Book Title: Recent Advances in Stroke Therapeutics Chapter-1 Publisher: NOVA Biomedical Science Publishers USA. pp. 1-24 URL:https://www.researchgate.net/publication/273061704_The_Immune_System_and_Str okes.
Manzoor A Mir, Raid S Albaradie and Malik Alhasanavi (2014) Pathophysiology of strokes, ISBN: 978-1-63117-754-5 Book Title: Recent Advances in Stroke Therapeutics Chapter-2 Publisher: NOVA Biomedical Science Publishers USA. pp. 25-80. URL: https://www.researchgate.net/publication/273061843_Pathophysiology_of_Strokes
Manzoor A Mir, Raid S Albaradie and Malik Alhasanavi (2014) Stem cells and treatment of strokes, ISBN: 978-1-63117-754-5 Book Title: Recent Advances in Stroke Therapeutics Chapter-5 Publisher: NOVA Biomedical Science Publishers USA. pp. 177- 204. URL:https://www.researchgate.net/publication/273061933_Stem_Cells_and_Treatment_of_Strokes
Manzoor A Mir, Raid S Albaradie and Malik Alhasanavi (2014) Inflammation and Anti-Inflammatory Agents in Strokes, ISBN: 978-1-63117-754-5 Book Title: Recent Advances in Stroke Therapeutics Chapter-3 Publisher: NOVA Biomedical Science Publishers USA.pp.81-110.URL: https://www.researchgate.net/publication/273061916_Inflammation_and_Anti- Inflammatory_Agents_in_Strokes
Manzoor A Mir, Raid S Albaradie and Malik Alhasanavi (2014) Major Advances in the Treatment of Strokes, ISBN: 978-1-63117-754-5 Book Title: Recent Advances in Stroke Therapeutics Chapter-4 Publisher: NOVA Biomedical Science Publishers USA. pp. 111- 177.URL: https://www.researchgate.net/publication/273061926_Major_Advances_in_the_ Treatment_of_Strokes
Manzoor A Mir, Abdul Rahman Obaid and Raid S Albaradie (2013) Costimulation in the Treatment of Lymphomas, ISBN: 978-1628085198, Book Title: Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas, Chapter-4, Publisher: Nova Science Publishers Inc. New York USA. pp. 150-172.URL: https://www.researchgate.net/publication/273061665_Costimulation_in_the_Treatment_of _Lymphomas
Manzoor A Mir, Abdul Rahman Obaid and Raid S Albaradie (2013) Costimulation in the Treatment of Lymphomas, ISBN: 978-1628085198, Book Title: Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas, Chapter-5, Publisher: Nova Science Publishers Inc.NewYorkUSA.pp.173-197.URL: https://www.researchgate.net/publication/273061721_Costimulation_and_Infectious_Disea ses
Manzoor A Mir, Abdul Rahman Obaid and Raid S Albaradie (2013) Costimulation in the Autoimmune Diseases, ISBN: 978-1628085198, Book Title: Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas, Chapter-3, Publisher: Nova Science Publishers Inc.NewYorkUSA.pp.85-149.URL: https://www.researchgate.net/publication/273061607_Costimulation_in_the_Autoimmune _Diseases
Manzoor A Mir, Abdul Rahman Obaid and Raid S Albaradie (2013) Regulation of Immune system by costimulatory molecules, ISBN: 978-1628085198, Book Title: Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas, Chapter-1, Publisher: Nova Science Publishers Inc. New York USA. pp. 1-37. URL: https://www.researchgate.net/publication/273061636_Regulation_of_Immune_system_by_ costimulatory_molecules
Manzoor A Mir, Abdul Rahman Obaid and Raid S Albaradie (2013) Costimulatory Pathways in Transplantation Therapeutics, ISBN: 978-1628085198, Book Title: Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas, Chapter-2, Publisher: Nova SciencePublishersInc.NewYorkUSA.pp.38-84.URL: https://www.researchgate.net/publication/273061651_Costimulatory_Pathways_in_Transpl antation_Therapeutics
Manzoor A Mir and Javed N Agrewala (2008) Dietary Polyphenols in Modulation of the Immune System, ISBN No. 978-1604563498, DOI: 10.13140/RG.2.1.4980.9449, Book Title : Polyphenols and Health: New and Recent Advances, Edition: First, Chapter: 10, Publisher: NOVA SciencePublisherNewYorkUSA,pp.245-272URL: https://www.researchgate.net/publication/273060751_Dietary_Polyphenols_in_Modulation of_the_Immune_System
Manzoor A Mir (2019) Natural Medicine in Cerebrovascular Diseases, ISBN No. 9789385497940, Book Title : Natural Medicine in Cerebrovascular Diseases, Edition: First, Chapter: 1, Publisher: Dilpreet Publishers New Delhi India, pp.1-127

List of representative Research publications

Umar Mehraj, Rais A Ganie, Muzaffar A Macha, Abid Hamid, Afzal Zargar, ...., Bader Alshehri Raid Albaradie, Nissar A Wani and Manzoor A Mir. The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities. Cellular Oncology 2021 Vol-44 (5) DOI No. https://doi.org/10.1007/s13402-021-00634-9 (ISSN 2211-3428) Publication URL: https://link.springer.com/article/10.1007%2Fs13402-021-00634-9#citeas [Impact Factor = 6.730]

Hina Qayoom, Bader Alshehri, Nissar A Wani and Manzoor A Mir. An Insight into the Cancer Stem Cell Survival Pathways Involved in Chemo-resistance in Triple Negative Breast cancer. Future Oncology 2021 Vol-17 (25) DOI No. https://doi.org/10.2217/fon-2021-0172 (ISSN 1479-6694) Publication URL: https://www.futuremedicine.com/doi/10.2217/fon-2021-0172 [Impact Factor = 3.404]

Hafsa Qadri, Munazah F Qureshi, Abdul H Shah*, Manzoor A Mir* (2021) "Glucose - The X factor for the survival of human fungal pathogens and disease progression in the host" Microbiological Research, 247(6): DOI No. 10.1016/j.micres.2021.126725 {ISSN: 0944-5013} Publication URL: https://www.sciencedirect.com/science/article/pii/S0944501321000318?via%3Dihub [Impact Factor = 5.415]

Mahak Majeed, Tanveer B Pirzadah, Manzoor A Mir, Khalid R Hakeem, Hesham F. Alharby, Hameed Alsamadany, Atif A. Bamagoos and Reiaz Ul Rehman (2021) "Comparative Study on Phytochemical Profile and Antioxidant Activity of an Epiphyte, Viscum album L. (White Berry Mistletoe), Derived from Different Host Trees" Plants, 10(6): DOI No. 10.3390/plants10061191 {ISSN: 2223-7747} Publication URL: https://www.mdpi.com/2223-7747/10/6/1191 [Impact Factor = 3.935]

Umar Mehraj, Hina Qayoom and Manzoor A. Mir* (2021) "Prognostic significance and targeting tumor-associated macrophages in cancer: new insights and future perspectives" Breast Cancer, 28(5): DOI No. 10.1007/s12282-021-01231-2 Publication URL: https://link.springer.com/article/10.1007%2Fs12282-021-01231-2 [Impact Factor = 4.234]

Umar Mehraj, Abid H Dar, Nissar A. Wani, Manzoor A. Mir* (2021) "Tumor microenvironment promotes breast cancer chemoresistance" Cancer Chemotherapy and Pharmacology, 87(2): DOI No. 10.1007/s00280-020-04222-w {ISSN: 1432-0843} Publication URL: https://link.springer.com/article/10.1007%2Fs00280-020-04222-w [Impact Factor = 3.333]

Hafsa Qadri , Abdul Haseeb, Manzoor A Mir (2021) “Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes” Current Drug Targets 22(12) DOI No. 10.2174/1389450121666201228123212 {ISSN: 1873-5592} Publication URL: https://www.eurekaselect.com/189516/article [Impact Factor = 3.465]

Manzoor A Mir, Hina Qayoom, Umar Mehraj, Safoora Nisar, Nisar A Wani (2020) Targeting Different Pathways Using Novel Combination Therapy in Triple Negative Breast Cancer. Current Cancer Drug Targets: ISSN:1568-0096 (P), 1873-5576 (O) 2020 Vol. 20, issue (5) pp: 1-15 DOI: 10.2174/1570163817666200518081955, http://www.eurekaselect.com/182060/article [ImpactFactor-3.428]

Samara Hafeez, Mehwish Urooj, Shamlala Saleem,., Mohd Asif, Manzoor A Mir and Mahmood Rasool. (2016) BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. PLoS ONE 11(1): e0145780. doi:10.1371/journal.pone.0145780 Publication URL: http://journals.plos.org/plosone/article?id=10.1371/ journal.pone.0145780 [Impact Factor= 4.240]

Bashir A Sheikh, Basharat A Bhat, Umar Mehraj, Wajahat Mir, Suhail Hamadani Manzoor A Mir. 2021, Development of New Therapeutics to Meet the Current Challenge of Drug Resistant Tuberculosis. Current Pharmaceutical Biotechnology: ISSN: 1389-2010 (P) 1873-4316(O)2019Vol.21,issue(9)pp:41-52 DOI No. 10.2174/1389201021666200628021702 Publication URL http://www.eurekaselect.com/183215/article [Impact Factor-2.837]

Marta Mila, Marina Garriga, Manzoor A Mir, Raid Al-Baradie, Mark Slevin and Jerzy Krupinski (2015) 123I-FP-CIT SPECT imaging, clinical diagnosis of common types of dementia and contribution of ischemia to brain damage Frontiers in Systems Neuroscience July 2015: Vol 9 Article 99 PP 1-11 Publication URL: http://journal.frontiersin.org/article/10.3389/fnsys. 2015.00099/full [Impact Factor-3.289]

Manzoor A Mir (2014) TNF Receptor Modulation by Gentiana Extracts Acts as Neuroprotective Mechanism in Stroke by Enhancing Cellular Survival. Stroke 2014; 45(12)e26(e259-e298) DOI: 10.1161/01.str.0000455918.04147.bf Publication URL: https://www.ahajournals.org/doi/epub/10.1161/01.str.0000455918.04147.bf [Impact Factor-7.919]

Manzoor A. Mir and Javed N. Agrewala. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin. Ther. Targets 12(8):Pp 1-11. DOI No. 10.1517/14728222.12.8.969 PublicationURL: https://www.tandfonline.com/doi/abs/10.1517/14728222.12.8.969?journalCode=iett20 [Impact Factor-6.902]

Awards, Fellowships & Scholarships at International/National Level

Awarded Teachers Summer Research Fellowship Programme (SRFP-2019) by Indian Academy of Sciences for an IASc-INSA-NASI vide No. SRFP- FT94 (2019) dated; 02- 04-2019
Awarded Teacher Associate Research Excellence Fellowship by Science and Engineering Research Board Department of Science and Technology SERB-DST Govt. of India in the year 2018 Vide No. TAR/2018/001213 dated: 05-11-2018
Awarded Faculty Position (Assistant Professor) in Immunology by College of Medicine, Department of Immunopathology, University of Shaqra, KSA for the year 2017 (1437) Vide No. 35114/53 Dated: 06-11-1437 (10th August 2016)
Awarded International Travel Grant by University Grants Commission (UGC) under 12th five year plan to attend the 14th Annual Congress of International Drug Discovery Science and Technology Nanjing, China from 16th-19th November 2016 Vide No. F (Deputation MAK)Res/KU/16, Dated: Oct -1st 2016.
Received International Travel Award from Majmaah University KSA to attend the European Stroke Research Organization Conference at International Convention Centre Glassgow UK 2015.
Awarded International Travel Award to attend Keystone Symposia at Silverthrone, Colarado Springs USA by Deanship of Research Majmaah University KSA from 9th to 14th Feberuary 2014 Vide No. ITA/US/14/MU Dated: 03-01-2014.
Awarded International Travel Grant by University of Basra to attend the 5th International Conference on Microbiology and Biotechnology at Basrah University from 2nd to 3rd April 2013 Vide No. F (Deputation/Int.Conf.)Res/KU/2059 Dated: March 30th, 2013.
Won First Prize in National Level Competition on ‘Role of Media in National Integration’ at Academic Staff College, Aligarh Muslim University Aligarh in the year 2011.
Won First Prize in UGC sponsored National Seminar on Sustenance of quality in Higher Education Some Initiatives at Govt. College of Education Srinagar in the year 2011.
Topped the Assistant Professor Selection List in Zoology published by Jammu and Kashmir Public Service Commission on 30-10-2009.
Won the FIRST PRIZE in Chandigarh Science Congress CHASCON-2008 at Post Graduate Institute of Medical Education and Research (PGIMER) and Punjab University Chandigarh in the year 2008.
Awarded Prestigious Senior Research Fellowship SRF by CSIR Govt of India in year 2006-2007.
Qualified Junior Research Fellow-National Educational Test (JRF-NET) conducted by UGC-CSIR Govt. of India in year 2005 under Roll 328164.
Qualified Junior Research Fellow-National Educational Test (JRF-NET) conducted by U.G.C-CSIR Govt. of India in year 2004 under Roll 322899.
Qualified Junior Research Fellow-National Eligibility Test (JRF-NET) conducted by UGC-CSIR Govt of India in year 2003 under Roll 313837.

Masters students Guided (Year wise List of students who completed their Projects)
2017-Batch
1	Miss Najwa Shabir
2	Mr. Mr. Gazi Shaban Shan
3	Mr. Mir Aadil
2018-Batch
1	Miss Snober Ali
2	Miss Aqiba Jan
3	Miss Durdana Bano
2019-Batch
1.		Mr. Umer Showkat
2.		Mr. Abdul Sami Wani
3.		Mr. Muzamil Mushtaq
2020-Batch
1.			Mr. Pzd. Farhana Anjum
2.			Miss Shazia Shafi
3.			Miss Shariqa Jan

Refresher and Orientation Courses completed

*S. No*	*Name of training course*	*Year, month and time* *period*	*Place of training course* *University/Institute*	*Grade* *Obtained*
1	Orientation Course	01-02-2011 to 01-03-2011	UGC-HRDC ASC Aligarh Muslim University	A
2	Refresher Course in Research Methodologies	16-01-2012 to 08-02-2012	UGC-HRDC ASCUniversity of Kashmir	A
3	Refresher Course in Bioscience	15-05-2017 to 03-06-2017	UGC-HRDC University of Kashmir	A
4	Refresher Course in Molecular Biology of Cell	23-10-2017 to 06-11-2017	Indian National Science Academy New Delhi	A
5	Workshop on MOOC Development	12-06-2019 to 19-06-2019	UGC-HRDC University of Kashmir	A
6	Workshop on ICT Technology in Education	24-11-2019 to 30-11-2019	MHRD and NIEPA New Delhi	A
7	Workshop on Capacity Building Programme For Swayam Course Coordinators	04-11-2019 to 06-11-2019	MHRD NITTTR Chandigarh	A
8	Workshop on Develop, Design and Deliver MOOC Course as a tool for blended learning	09-01-2020 to 14-01-2020	PMMMNM GNDU Amritsar	A
9	One week Faculty development Programme (FDP) on Moodle Learning Management system	04-05-2020 to 8-05-2020	KSLVDIT and IIT Bombay through NME	-
10	One week Faculty development Programme (FDP) on PHP and MySQL	18-05-2020 to 23-05-2020	JNTUH Telangana and IIT Bombay	-
11	Refresher Course on Information and communication Technology ICT Cert.ID: HRDC-RCICT-164	24-08-2020 to 05-09-2020	UGC-HRDC University of Hyderabad	A+
12	Two week Training course cum Refresher Course on “Research tool Preparation”	16-10-2020 to 29-10-2020	PMMMNM GNDU Amritsar	A

Useful Links

Amazon International Books Published

https://www.amazon.com/Manzoor-Ahmad-Mir/e/B00MW5O28M

ORCID:

https://orcid.org/0000-0003-3297-1402

Research Gate:

https://www.researchgate.net/profile/Manzoor_Mir2/research

Google Scholar

https://scholar.google.com/citations?user=vPREzKEAAAAJ&hl=en

Research Expertise and Techniques known:

Microbial Immunology:

Experience of working and handling virulent Mycobacteria (M. tuberculosis H37Rv) in BSL-3, culture and maintenance of M. tuberculosis H37Rv, M. tuberculosis H37Ra and M. microti in broth base (7H9 Broth), agar base (7H10 Agar with or without OADC or ADC) and on Lowenstein-Jensen slants.

Expertise in animal handling: (BSL-3 Laboratory)

Retro-orbital bleeding, bleeding from the ear lobe and immunization of animals (Mice, Rat, Guinea Pigs and Rabbit) for the generation of polyclonal antibodies etc. Infection of mice with Mycobacterium tuberculosis, Mycobacterium. microti etc

Tissue culture Related:

Maintenance of different mammalian cell lines (EL-4, WEHI-279, THP-1, HuT-78, JM-1, J774A.1, Jurkat, COS-7 etc.), experience of handling BALB/c, C57BL/6, C3He mice for isolation of peritoneal macrophages, splenocytes, Dendritic cells etc. Purification of naïve T cells and B cells by density gradient centrifugation, purification of dendritic cells from spleen and bone marrow, preparation of Baby rabbit complement, purification of monoclonal antibody from culture supernatant by using sepharose protein A and G columns and other cellular immunological techniques.

Instruments conversant with:

Flow-cytometer, Fluorescence microscope, Phosphor-Imager, Confocal microscope, Gel-doc, beta counter, Inverted microscope, Flourimeter and Luminometer, ELISA reader, Spectrophotometer, Sonicator, Centrifuges (RC5C, RC3C, table-top) etc.

Expertise in FACS

Acquisition and analysis: Immuno-fluorescence staining of cell surface molecules (Two colour as well as Multi-colour) and intracellular staining of cytokines, expertise in Cell Quest and FACS PRO-Software’s of FACS acquisition and Analysis, Detection of apoptosis by PI staining.

Mobile App URL

https://play.google.com/store/apps/details?id=net.kashmiruniversity&pcampaignid=web_share

Student Form

https://bioresources.uok.edu.in/Main/UserForm.aspx?Form=SF