Dr. Manzoor Ahmad Mir

M. Sc, Ph. D.  PGDHE (CSIR JRF-NET)

Senior Assistant Professor (Stage-III)

Coordinator/Head

Department of Bioresources

School of Biological Sciences

University of Kashmir, Srinagar-190006  J&K India.

Mobile: +919622901319, 7006325036

drmanzoor@kashmiruniversity.ac.in      mirmanzoor110@gmail.com

 

Research Interests   (Immunobiology of Stroke, Cancer and Infectious diseases)

 

  • An alteration in the metabolism of cancer cells is considered to be fundamentally connected to the transformation of a normal cell to a cancerous cell. Unlike the normal cells, cancer cells exhibit glycolysis even in the presence of oxygen. This “aerobic glycolysis” or Warburg effect may be the result of abnormalities like mitochondrial damage, adaptation to hypoxia within tumors, oncogenic stimuli and particularly over expression of glycolytic enzymes which in turn support cancer cell survival and proliferation. In cancer cells lipogenesis, like glycolysis, is also regulated by oncogenic pathways and is considered to be responsible for tumor survival, initiation, progression and aggressiveness. Targeting PI3K, which is the most proximal component of the glycolytic pathway, is a more suitable approach than targeting any of the more distal components like Akt and mTOR. This is because inhibiting the PI3K component provides a broader and earlier inhibition of all the signals that are downstream to it like Rac and mTOR. Additionally, PI3K inhibition overcomes the possibility of increased proliferation which might be triggered due to the activation of the pathway by a feedback loop and/or crosstalk with Ras/Raf/Mek/Erk pathway. So our target is to screen and evaluate of PI3K-Akt-mTOR-CDK targets by dual inhibition cum combinatorial approach.
  • Macrophages are a fundamental part of the innate defense mechanisms, which can promote specific immunity by inducing T cell recruitment and activation. Despite this, their presence within the tumour microenvironment has been associated with enhanced tumour progression and shown to promote cancer cell growth and spread, angiogenesis and immunosuppression. This paradoxical role of macrophages in cancer finds an explanation in their functional plasticity that may result in the polarized expression of either pro- or anti-tumoural functions. Generally, in the presence of different signals, macrophages may undergo classical M1 activation (stimulated by TLR ligands and IFN-γ) or alternative M2 activation (stimulated by IL-4/IL-13). M1 phenotype is characterized by the expression of high levels of proinflammatory cytokines, high production of reactive nitrogen and oxygen intermediates, promotion of Th1 response, and strong microbicidal and tumoricidal activity.  In contrast, M2 macrophages are considered to be involved in parasite containment and promotion of tissue remodeling and tumor progression and to have immunoregulatory functions. so our target is to explore the role of altered tumor microenvironment on angiogenesis, metastasis and tumor inhibition.
  • Tuberculosis (TB) has been the subject of control programs since prehistoric times, but still it remains a serious challenge to public health programmes. TB remains an enormous health and economic problem not only in developing regions but also in high-income countries due to emergence of drug resistant TB (DR-TB) and TB-HIV co-infection. Drug resistance is a costly consequence of pathogen’s evolution and a major concern in public health. India has the highest TB burden among all the countries in the world and accounts for one fourth of the global TB burden. Global TB Report 2016 confirms that India has the highest burden of both drug susceptible and drug resistant TB throughout the world. Improving TB control requires a better understanding of impact of the environment on the interaction between the pathogen and its host i.e. population based examination of prevalence of drug resistance, their susceptibility patterns, their genetic setup etc. study will be the population-based to find the molecular basis of Drug and MDR-TB in Kashmir and its findings will lead to a better understanding of the emergence of drug and multi-drug resistance at population level. Those in turn will provide the type of data needed to improve local and national TB control programs also. Further our group will focus on to elucidate the molecular mechanism involved in drug and multidrug resistance in bacterial pathogens like mycobacteria and Slamonella.

 MOOC Courses Developed with MHRD Ministry Govt of India

1. MOOC on Immunology

         https://onlinecourses.swayam2.ac.in/cec20_bt05/preview

 2. MOOC on Endocrinology

        https://onlinecourses.swayam2.ac.in/cec20_bt21/preview

 B. MOOC Course successfully Completed with Certification from NPTEL

 1.  Introduction to Research by NPTEL (Roll No. NPTEL20GE04S1316278)

      https://onlinecourses.nptel.ac.in/noc20_ge04/preview

C. MOOC Courses Ongoing through SWYAM

1. Human Genetics by CEC-UGC MHRD 

      https://onlinecourses.swayam2.ac.in/cec20_bt17/preview

2. Immunology by NPTEL MHRD

      https://onlinecourses.nptel.ac.in/noc20_bt43/preview

3.  Enzymology by CEC-UGC MHRD

      https://onlinecourses.swayam2.ac.in/cec20_bt20/preview

4.  Cancer Fundamentals by AICTE MHRD

      https://onlinecourses.swayam2.ac.in/aic20_ge02/preview

5.  Intellectual Property (IP) by CEC-UGC-MHRD

    https://onlinecourses.swayam2.ac.in/cec20_hs18/preview

 Research Grants:

S. No/ File No. of Project

       Title of the project

    Funding Agency

TAR/2018/001213

Dated: 05-11-2018

Elucidation of Molecular Basis of …………Tuberculosis Resistance of mycobacterium tuberculosis in Kashmir Valley

SERB-DST-India   

P-3  SATCAS-03/2013/MU  

Dated: 06-10-2013

TNF receptor modulation and its impact on the cellular survival ……in OGD model of stroke

SATCAS-MU-KSA

P-18 BHSRC-18/2014/MU

Dated: 21-08-2014

Neuroprotective effect of E. densa …..…in cellular survival after cerebral ischemia in oxidative/inflammatory in vitro model of Stroke

BHSRC-MU-KSA

Lab Members of Dr. Manzoor

Ph. D students

S.N

Name

Awards

1

Mr. Umar Mehraj Sheikh

JRF-CSIR

2

Miss Mehak Majeed

JRF-CSIR

3

Mr. Bashir Ahmad Sheikh

NET-CSIR, SET-JK

4

Mr. Wahjahat Rashid

UGC-NET, JRF-MANAF

Miss Safura Nisar

6.

Miss Hafsa Qadri

 JRF (DST-SERB Project)

7

Miss Hina Qayoom

 

8

Mr Basharat Ahmad

 M. Phil

Publications:

   List of Representative International Books Published in Thompson Reuters (ISI) Web of Science

  1.  Manzoor A Mir (2015) Developing Costimulatory Molecules for Immunotherapy of Diseases Elsevier Publishers USA ISBN (Print) ISBN (ebook) 9780128026755: 978-0-12-80-2585-7 26th May 2015, Pp 322 URL: http://store.elsevier.com/Developing-Costimulatory-Molecules-forImmunotherapy- of Diseases  /Manzoor-Ahmad-Mir/isbn-9780128026755/
  2. Manzoor A. Mir (2020). Basics and Fundamentals of Immunology (Text Book), ISBN: 978-1-53616-639-2 Nova Biomedical Science Publishers USA (ISI-Web of Science) June 2019 Pg. No.:1-334 https://novapublishers.com/shop/basics-and-fundamentals-of-immunology/
  3. Manzoor A. Mir (2019). Plant Metabolites in the Treatment of Cancer and cerebrovascular Diseases ISBN: 978-1-63278-073-7, DOI: 10.4172/978-1-63278-073-7, OMICS International Publishers UK. July, 2019 Pg. No.:1-176
  4. Manzoor A. Mir (2020). Immunoglobulins, Magic Bullets and Therapeutic Antibodies (Text Book), ISBN: 978-1-53616-903-4, Nova Science Publishers Newyork USA (ISI-Web of Science) October 2019 Pg. No.:1-365 https://novapublishers.com/shop/immunoglobulins-magic-bullets-and-therapeutic-antibodies/
  5. Manzoor A. Mir (2020). Cytokines and their Therapeutic potential (Text Book), ISBN: 978-1-53617-017-7 , Nova Science Publishers Newyork USA (ISI-Web of Science) November 2019 Pg. No.:1-285 https://novapublishers.com/shop/cytokines-and-their-therapeutic-potential/
  6. Manzoor A Mir and Raid S Albaradie (2015) Natural Herbs in the Prevention and treatment of Stroke Nova Science Publishers Inc USA. ISBN: 978-1-63483-555-8. 2015 Pp;250
  7. Manzoor A. Mir, Raid S Albaradie and Malik D Alhusainwi (2014) Recent Advances in Stroke Therapeutics. ISBN: 978-1-62808-521-4 (P), e-book ISBN: 978-1-63117-754-5 April 2014 Nova Biomed. Science Inc. Publishers USA. April, 2014. Pp 1-252. Publication   URL: https://www.novapublishers.com/catalog/product_info.php?products_id=49332&osCsid=4 c7e974c9cae59f2482a5ede69ff5af5
  8. Manzoor A Mir, Raid S Albaradie and Abdul R Alharbi Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas: 2013 ISBN:978-1-62808-519-8 Nova URL:https://www.novapublishers.com/catalog/productinfo.php?products_id=46107&osCsid=4c7e974c9cae59f2482a5ede69ff5af5
  9. Manzoor A Mir, The fundamentals of Hypersensitivities and Allergies: (2019). Nova Biomedical Science Publishers   New York USA, ISBN: 978-1-53617-012-2, Pp 1-185.
  10. Manzoor A. Mir, Raid S Albaradie and Javed N. Agrewala. (2013) Cancer and Infectious Diseases: Modern Approaches of Treatment ISBN No. 978-3-659-39067-8 Lam. Pub. Germany. Publication URL: http://www.amazon.com/Cancer-Infectious-Diseases- approaches-treatment/dp /3659390674
  11. Manzoor A Mir (2019) Natural Medicine in Cerebrovascular Diseases, ISBN No. 9789385497940, Book Title : Natural Medicine in Cerebrovascular Diseases, Edition: First Publisher: Ariana/Dilpreet Publishers New Delhi India, pp.1-127

 List of Representative Book Chapters published in Thompson Reuters ISI Web of Science

  1. Manzoor A Mir (2015) Concept of Reverse Costimulation and Its Role in Diseases, ISBN No. 978-0-12-802585-7, DOI: 10.1016/B978-0-12-802585-7.00002-9, Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First, Chapter: 2, Publisher: Elsevier Publishers USA, pp.45-81URL: https://www.sciencedirect.com/science/article/pii/B9780128025857000029
  2. Manzoor A Mir (2015) T-Cell Costimulation and Its Applications in Diseases, ISBN No.                      978-0-12-802585-7,DOI: 10.1016/B978-0-12-802585-7.00006-6,Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First Edition, Chapter: 6, Publisher: Elsevier Publishers USA, pp.255-292 URL: https://www.sciencedirect.com/science/article/pii/B9780128025857000054
  3. Manzoor A Mir (2015) Costimulation Immunotherapy in Allergies and Asthma, ISBN No. 978-0-12-802585-7, DOI: 10.1016/B978-0-12-802585-7.00004-2, Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First Edition, Chapter: 4, Publisher: Elsevier PublishersUSA,pp.131-184URL: https://www.sciencedirect.com/science/article/pii/B9780128025857000042
  4. Manzoor A Mir (2015) Introduction to Costimulation and Costimulatory Molecules, ISBN No. 978-0-12-802585-7, DOI: 10.1016/B978-0-12-802585-7.00001-7, Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First, Chapter: 1, Publisher: Elsevier Publishers USA, pp.1-43 URL:https://www.sciencedirect.com/science/article/pii/B9780128025857000017
  5. Manzoor A Mir (2015) Costimulation Immunotherapy in Infectious Diseases, ISBN No.                     978-0-12-802585-7,DOI: 10.1016/B978-0-12-802585-7.00003-0,Book Title: Developing  Costimulatory Molecules for Immunotherapy of Diseases, Edition: First, Chapter: 3, Publisher: Elsevier Publishers USA, pp.83-129 URL: https://www.sciencedirect.com/science/article/pii/B9780128025857000030
  6. Manzoor A Mir (2015) Costimulation in Lymphomas and Cancer, ISBN No. 978-0- 12-802585-7, DOI: 10.1016/B978-0-12-802585-7.00005-4, Book Title: Developing Costimulatory Molecules for Immunotherapy of Diseases, Edition: First, Chapter: 5, Publisher: Elsevier Publishers USA, pp.185-254URL: https://www.sciencedirect.com/science/article/pii/B9780128025857000054
  7. Manzoor A Mir (2015) An Introduction to Cerebrovascular Diseases ISBN: 978-1- 63483-555-8, Book Title: Role of Natural Herbs in Stroke Prevention and Treatment Chapter-1 Publisher: NOVA Science Publishers USA .pp.1-36. URL: http://www.novapublishers.org/catalog/product_info.php?products_id=55796
  8. Manzoor A Mir (2015) Immunobiology of Stroke ISBN: 978-1-63483-555-8, Book Title: Role of Natural Herbs in Stroke Prevention and Treatment Chapter-2 Publisher: NOVA Science Publishers USA .pp.37-106. URL: http://www.novapublishers.org/catalog/product_info.php?products_id=55796
  9. Manzoor A Mir (2015) Natural Herbs, Human Brain and Neuroprotection ISBN: 978- 1-63483-555-8, Book Title: Role of Natural Herbs in Stroke Prevention and Treatment Chapter-3 Publisher: NOVA Science Publishers USA. pp. 107-168. URL: http://www.novapublishers.org/catalog/product_info.php?products_id=55796
  10. Manzoor A Mir (2015) Natural Herbs in Stroke prevention and Treatment ISBN: 978-1-63483-555-8, Book Title: Role of Natural Herbs in Stroke Prevention and Treatment Chapter-4 Publisher: NOVA Science Publishers USA. pp. 169-204. URL: http://www.novapublishers.org/catalog/product_info.php?products_id=55796
  11. Manzoor A Mir (2015) Polyphenols from Natural Herbs in Neuroprotection ISBN: 978-1-63483-555-8, Book Title: Role of Natural Herbs in Stroke Prevention and Treatment Chapter-5 Publisher: NOVA Science Publishers USA. pp. 205-238. URL:http://www.novapublishers.org/catalog/product_info.php?products_id=55796
  12. Manzoor A Mir Raid S Albaradie and Malik Alhasanavi (2014) Immune System and Strokes ISBN: 978-1-63117-754-5 Book Title: Recent Advances in Stroke Therapeutics Chapter-1 Publisher: NOVA Biomedical Science Publishers USA. pp. 1-24 URL:https://www.researchgate.net/publication/273061704_The_Immune_System_and_Strokes.
  13. Manzoor A Mir, Raid S Albaradie and Malik Alhasanavi (2014) Pathophysiology of strokes, ISBN: 978-1-63117-754-5 Book Title: Recent Advances in Stroke Therapeutics Chapter-2 Publisher: NOVA Biomedical Science Publishers USA. pp. 25-80. URL:  https://www.researchgate.net/publication/273061843_Pathophysiology_of_Strokes
  14. Manzoor A Mir, Raid S Albaradie and Malik Alhasanavi (2014) Stem cells and treatment of strokes, ISBN: 978-1-63117-754-5 Book Title: Recent Advances in Stroke Therapeutics Chapter-5 Publisher: NOVA Biomedical Science Publishers USA. pp. 177- 204. URL:https://www.researchgate.net/publication/273061933_Stem_Cells_and_Treatment_of_Strokes
  15. Manzoor A Mir, Raid S Albaradie and Malik Alhasanavi (2014) Inflammation and Anti-Inflammatory Agents in Strokes, ISBN: 978-1-63117-754-5 Book Title: Recent Advances in Stroke Therapeutics Chapter-3 Publisher: NOVA Biomedical Science Publishers USA.pp.81-110.URL: https://www.researchgate.net/publication/273061916_Inflammation_and_Anti- Inflammatory_Agents_in_Strokes
  16. Manzoor A Mir, Raid S Albaradie and Malik Alhasanavi (2014) Major Advances in the Treatment of Strokes, ISBN: 978-1-63117-754-5 Book Title: Recent Advances in Stroke Therapeutics Chapter-4 Publisher: NOVA Biomedical Science Publishers USA. pp. 111- 177.URL: https://www.researchgate.net/publication/273061926_Major_Advances_in_the_ Treatment_of_Strokes
  17. Manzoor A Mir, Abdul Rahman Obaid and Raid S Albaradie (2013) Costimulation in the Treatment of Lymphomas, ISBN: 978-1628085198, Book Title: Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas, Chapter-4, Publisher: Nova Science Publishers Inc. New York USA. pp. 150-172.URL: https://www.researchgate.net/publication/273061665_Costimulation_in_the_Treatment_of_Lymphomas
  18. Manzoor A Mir, Abdul Rahman Obaid and Raid S Albaradie (2013) Costimulation in the Treatment of Lymphomas, ISBN: 978-1628085198, Book Title: Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas, Chapter-5, Publisher: Nova Science Publishers Inc.NewYorkUSA.pp.173-197.URL: https://www.researchgate.net/publication/273061721_Costimulation_and_Infectious_Disea ses
  19. Manzoor A Mir, Abdul Rahman Obaid and Raid S Albaradie (2013) Costimulation in the Autoimmune Diseases, ISBN: 978-1628085198, Book Title: Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas, Chapter-3, Publisher: Nova Science Publishers Inc.NewYorkUSA.pp.85-149.URL: https://www.researchgate.net/publication/273061607_Costimulation_in_the_Autoimmune_Diseases
  20. Manzoor A Mir, Abdul Rahman Obaid and Raid S Albaradie (2013) Regulation of Immune system by costimulatory molecules, ISBN: 978-1628085198, Book Title: Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas, Chapter-1, Publisher: Nova Science Publishers Inc. New York USA. pp. 1-37. URL: https://www.researchgate.net/publication/273061636_Regulation_of_Immune_system_by_ costimulatory_molecules
  21. Manzoor A Mir, Abdul Rahman Obaid and Raid S Albaradie (2013) Costimulatory Pathways in Transplantation Therapeutics, ISBN: 978-1628085198, Book Title: Costimulation Immunotherapy for Autoimmunity, Transplantation and Lymphomas, Chapter-2, Publisher: Nova SciencePublishersInc.NewYorkUSA.pp.38-84.URL: https://www.researchgate.net/publication/273061651_Costimulatory_Pathways_in_Transpl antation_Therapeutics
  22. Manzoor A Mir and Javed N Agrewala (2008) Dietary Polyphenols in Modulation of the Immune System, ISBN No. 978-1604563498, DOI: 10.13140/RG.2.1.4980.9449, Book Title : Polyphenols and Health: New and Recent Advances, Edition: First, Chapter: 10, Publisher: NOVA SciencePublisherNewYorkUSA,pp.245-272URL: https://www.researchgate.net/publication/273060751_Dietary_Polyphenols_in_Modulation of_the_Immune_System
  23. Manzoor A Mir (2019) Natural Medicine in Cerebrovascular Diseases, ISBN No. 9789385497940, Book Title : Natural Medicine in Cerebrovascular Diseases, Edition: First, Chapter: 1, Publisher: Dilpreet Publishers New Delhi India, pp.1-127

  List of representative Research publications

 1. Manzoor A Mir, Hina Qayoom, Umar Mehraj, Safoora Nisar, Nisar A Wani. Targeting Different Pathways Using Novel Combination Therapy in Triple Negative Breast Cancer. Current Cancer Drug Targets: ISSN:1568-0096 (P), 1873-5576 (O) 2020 Vol. 20, issue (5) pp: 1-15 DOI:10.2174/1570163817666200518081955http://www.eurekaselect.com/182060/article

2. Manzoor A Mir and Umar Mehraj. Double-Crosser of the Immune System: Macrophages in tumor progression and metastasis. Curr Rev Immunol 15 (2). 172-184, 2019. ISSN: 1573-3955 (P), 1875-631X (O)(DOI. 10.2174/1573395515666190611122818). http://www.eurekaselect.com/172492/articl

3. Manzoor A Mir, Umar Mehraj, Sheikh Bashir and Syed Suhail. Nanobodies: the magic bullets in therapeutics, drug delivery and diagnostics. Human Antibodies (DOI. 10.3233/HAB 190390) ISSN: 1875-869X(0), 1093-2607 (P) 2019; 28 (1): 29-51 https://www.ncbi.nlm.nih.gov/pubmed/31322555

4. Manzoor A Mir, Umar Mehraj, Sheikh Bashir. Recent Advances in Chemotherapeutic Implications of Deguelin, A Plant Derived Retinoid. The Natural Products Journal ISSN:2210-3155, (P)2210-3163(O) 10 (3) 2019 Pp3-15 DOI: 10.2174/2210315510666200128125950  http://www.eurekaselect.com/178741/article

5. Manzoor A Mir, Umar Mehraj, Sheikh Bashir and Syed Suhail Metabolites from Medicinal Plants in Cancer Prevention and Treatment. Current Immunology Reviews ISSN: 1573-3955 (P), 1875-631X (O)  15(2) 2019 Pp-185-201 DOI: 10.2174/1573395515666191102094330  http://www.eurekaselect.com/176343/article

6. Samara Hafeez, Mehwish Urooj, Shamlala Saleem,., Mohd Asif, Manzoor A Mir and  Mahmood Rasool. (2016) BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. PLoS ONE 11(1): e0145780. doi:10.1371/journal.pone.0145780PublicationURL http://journals.plos.org/plosone/article?id=10.1371/ journal.pone.0145780

7. Manzoor A Mir MA, Shabir N, Mehraj U, Rather YM, Farhat S. Studies on the quality control analysis of antiepileptic drugs using high-performance liquid chromatography.  Int J Pharma Investig 2018;8:11 5-21 DOI 10.4103/jphi.JPHI_45_18     Publication URL http://www.jpionline.org/index.php/ijpi/article/view/261

8. Manzoor A Mir, Bashir A Sheikh, Basharat A Bhat, Umar Mehraj, Wajahat R Mir, Syed Suhail. Development of New Therapeutics to Meet the Current Challenge of Drug Resistant Tuberculosis. Current Pharmaceutical Biotechnology: ISSN: 1389-2010 (P) 1873-4316(O)2019Vol.21,issue(9)pp:41-52 http://www.eurekaselect.com/183215/article

9. Marta Mila, Marina Garriga, Manzoor A Mir, Raid Al-Baradie, Mark Slevin and Jerzy Krupinski (2015) 123I-FP-CIT SPECT imaging, clinical diagnosis of common types of dementia and contribution of ischemia to brain damage Frontiers in Systems Neuroscience July 2015: Vol 9 Article 99 PP 1-11 Publication URL: http://journal.frontiersin.org/article/10.3389/fnsys. 2015.00099/full

10.Manzoor A Mir and Raid S Albaradie (2015) Immunomodulation of Inflammatory Markers in Activated Macrophages by Leaf Extracts of Gingko Biloba. Advances in Neuroimmune Biology 6(1) 9–17 ISSN No. 1878-948X (P) 1878-9498 (O). Publication URL: https://content.iospress.com/articles/advances-in-neuroimmune-biology/nib150103.

11. Manzoor A Mir and Raid S Albaradie (2015) Inflammatory Mechanisms as Potential Therapeutic  Targets in Stroke     Advances in Neuroimmune Biology 5 (2014) 199–216 ISSN No.1878-948X(P)1878-9498 (O) Publication URL:http://iospress.metapress.com/content/c80h12l5l7r68097/?p=a770de5e3ec3426580f36714f 0c799da&pi=0

12.  Manzoor A Mir (2014) TNF Receptor Modulation by Gentiana Extracts Acts as Neuroprotective Mechanism in Stroke by Enhancing Cellular Survival. Stroke 2014; 45(12)e26(e259-e298) DOI: 10.1161/01.str.0000455918.04147.bf  PublicationURL https://www.ahajournals.org/doi/epub/10.1161/01.str.0000455918.04147.bf 

http://stroke.ahajournals.org/content/early/ 2014/11/04/01 str.0000455918. 04147.bf.full.pdf  

13.  Manzoor A Mir, Raid S Albaradie and Agrewala JN. (2013) Innate-effector immune response elicitation against tuberculosis through Anti-B7-1 (CD80) and Anti-B7-2 (CD86) signaling in macrophages. IJBPAS, May, 2013, 2(5): 1024-1043 ISSN No. 2277–4998. PublicationURL:     http://ijbpas.com/pdf/1366970831MS% 20IJBPAS%202013%201450.pdf

14.  Manzoor A Mir and Raid S Albaradie. Tuberculosis time bomb a global emergency: urgent need for alternative vaccines. Majmaah J. Health Sciences 2013. Vol. 1 No. 1 Pp 87-93. ISSN: 1658-645X Publication URL:https://www.semanticscholar.org/paper/TUBERCULOSIS-TIMEBOMB-A-GLOBAL-EMERGENCY%3A-NEED-FOR-Mir-Albaradie/2bd840f6769e7c20bbb6be6bf3870e526dce2591

http://www.mu.edu.sa/sites/default/files/ 11.%20Manzoor%20%2884-89%29.pdf

15. Manzoor A. Mir and Javed N. Agrewala. (2007) Influence of CD80 and CD86 costimulation in the modulation of the activation of APCs. Curr. Immunol. Rev. vol.3 No.3: Pp 160-169. ISSN No. 1875-631X (O) 1573-3955 (P) DOI: 10.2174/157339507781483487 Publication URL: http://eurekaselect.com/78686

16. Manzoor A. Mir and Javed N. Agrewala. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin. Ther. Targets 12(8):Pp 1-11. (doi: 10.1517/14728222.12.8.969)PublicationURL: http://www.ncbi.nlm.nih.gov/pubmed/18620519

17. Manzoor A Mir, Raid S Albaradie (2013) Hypersensitive allergic reactions are caused by Pollen abundantly found in air during the spring and autumn seasons Int. J. Pure App. Biosci.  1 (3): 68-80      (2013) ISSN: 23207051. Publication URL: http://www.ijpab.com/form/2013%20Volume%201,%20issue%203/IJPAB-2013-1-3-68-80.pdf

18. Manzoor A Mir Raid S Albaradie Amal A Otaibi, and Jehan Y Elrazkey (2015) Effect of Supine Versus Semi-Fowler’s Position on Hemodynamic stability of patients with Head injury. World J of Phar Res. Vol 4 Issue 4  pp 1559-1569 ISSN No. 2277-7105. Publication URL: http://www.wjpr.net/download/article/1427890784.pdf

19.Manzoor A. Mir and Javed N. Agrewala. (2007) Influence of CD80 and CD86 costimulation in the modulation of the activation of APCs. Curr. Immunol. Rev. vol.3 No.3: Pp 160-169. ISSN No. 1875-631X (O) 1573-3955 (P) DOI: 10.2174/157339507781483487  Publication URL: http://eurekaselect.com/78686

 Awards, Fellowships & Scholarships at International/National Level

  1.  Awarded Teachers Summer Research Fellowship Programme (SRFP-2019) by Indian Academy of Sciences for an IASc-INSA-NASI vide No. SRFP- FT94 (2019) dated; 02- 04-2019
  2. Awarded Teacher Associate Research Excellence Fellowship by Science and Engineering Research Board Department of Science and Technology              SERB-DST Govt. of India in the year 2018 Vide No. TAR/2018/001213 dated: 05-11-2018
  3. Awarded Faculty Position (Assistant Professor) in Immunology by College of Medicine, Department of Immunopathology, University of Shaqra, KSA for the year 2017 (1437) Vide No. 35114/53 Dated: 06-11-1437 (10th August 2016)
  4. Awarded International Travel Grant by University Grants Commission (UGC) under 12th five year plan to attend the 14th Annual Congress of International Drug Discovery Science and Technology Nanjing, China from 16th-19th November 2016 Vide No. F (Deputation MAK)Res/KU/16, Dated: Oct -1st 2016.
  5. Received International Travel Award from Majmaah University KSA to attend the European Stroke Research Organization Conference at International Convention Centre Glassgow UK 2015.
  6. Awarded International Travel Award to attend Keystone Symposia at Silverthrone, Colarado Springs USA by Deanship of Research Majmaah University KSA from 9th to 14th Feberuary 2014 Vide No. ITA/US/14/MU Dated: 03-01-2014.
  7. Awarded International Travel Grant by University of Basra to attend the 5th International Conference on Microbiology and Biotechnology at Basrah University from 2nd to 3rd April 2013 Vide No. F (Deputation/Int.Conf.)Res/KU/2059 Dated: March 30th, 2013.
  8. Won First Prize in National Level Competition on ‘Role of Media in National Integration’ at Academic Staff College, Aligarh Muslim University Aligarh in the year 2011.
  9. Won First Prize in UGC sponsored National Seminar on Sustenance of quality in Higher Education Some Initiatives at Govt. College of Education Srinagar in the year 2011.
  10. Topped the Assistant Professor Selection List in Zoology published by Jammu and Kashmir Public Service Commission on 30-10-2009.
  11. Won the FIRST PRIZE in Chandigarh Science Congress CHASCON-2008 at Post Graduate Institute of Medical Education and Research (PGIMER) and Punjab University Chandigarh in the year 2008.
  12. Awarded Prestigious Senior Research Fellowship SRF by CSIR Govt of India in year 2006-2007.
  13. Qualified Junior Research Fellow-National Educational Test (JRF-NET) conducted by UGC-CSIR Govt. of India in year 2005 under Roll 328164.
  14. Qualified Junior Research Fellow-National Educational Test (JRF-NET) conducted by U.G.C-CSIR Govt. of India in year 2004 under Roll 322899.
  15. Qualified Junior Research Fellow-National Eligibility Test (JRF-NET) conducted by UGC-CSIR Govt of India in year 2003 under Roll 313837.

Masters students Guided  (Year wise List of students who completed their Projects)

2017-Batch

1

Miss Najwa Shabir

2

Mr. Mr. Gazi Shaban Shan

3

Mr. Mir Aadil

2018-Batch

1

Miss Snober Ali

2

Miss Aqiba Jan

3

Miss Durdana Bano

2019-Batch

1.

Mr. Umer Showkat

2.

Mr. Abdul Sami Wani

3.

Mr. Muzamil Mushtaq

2020-Batch

1.

Mr. Pzd. Farhana Anjum

2.

Miss Shazia Shafi

3.

Miss Shariqa Jan

 

Refresher and Orientation Courses completed 

S. No

Name of training course

Year, month and time

period

Place of training course

University/Institute

Grade

Obtained

 

1

Orientation Course

01-02-2011 to 01-03-2011

UGC-HRDC ASC

Aligarh Muslim University

 

A

 2

Refresher Course in Research Methodologies

16-01-2012 to 08-02-2012

UGC-HRDC ASCUniversity of Kashmir

A

 3

Refresher Course in Bioscience

15-05-2017 to 03-06-2017

UGC-HRDC University of Kashmir

A

 4

Refresher Course in Molecular Biology of Cell

23-10-2017 to 06-11-2017

Indian National Science Academy New Delhi

A

 5

Workshop on MOOC Development

12-06-2019 to 19-06-2019

UGC-HRDC University of Kashmir

A

 6

Workshop on ICT Technology in Education

24-11-2019 to 30-11-2019

MHRD and NIEPA New Delhi

A

7

Workshop on Capacity Building Programme For Swayam Course Coordinators

04-11-2019 to 06-11-2019

MHRD NITTTR Chandigarh

A

8

Workshop on Develop, Design and Deliver MOOC Course as a tool for blended learning

09-01-2020 to 14-01-2020

PMMMNM GNDU Amritsar

A

9

One week Faculty development Programme (FDP) on Moodle Learning Management system

04-05-2020 to 8-05-2020

KSLVDIT and IIT Bombay through NME

-

10

One week Faculty development Programme (FDP) on PHP and MySQL

18-05-2020 to 23-05-2020

JNTUH Telangana and IIT Bombay

-

11

Refresher Course on Information and communication Technology  ICT Cert.ID: HRDC-RCICT-164

 24-08-2020 to 05-09-2020

UGC-HRDC University of Hyderabad

A+

12

Two week Training course cum Refresher Course on “Research tool Preparation” 

16-10-2020 to 29-10-2020

PMMMNM GNDU Amritsar

A

 Useful Links 

Amazon International Books Published

https://www.amazon.com/Manzoor-Ahmad-Mir/e/B00MW5O28M

ORCID: 

https://orcid.org/0000-0003-3297-1402

Research Gate:

https://www.researchgate.net/profile/Manzoor_Mir2/research 

Google Scholar

https://scholar.google.com/citations?user=vPREzKEAAAAJ&hl=en

Research Expertise and Techniques known:

   Microbial Immunology:                       

Experience of working and handling virulent Mycobacteria (M. tuberculosis H37Rv) in BSL-3, culture and maintenance of M. tuberculosis H37Rv, M. tuberculosis H37Ra and M. microti in broth base (7H9 Broth), agar base (7H10 Agar with or without OADC or ADC) and on Lowenstein-Jensen slants.

  Expertise in animal handling: (BSL-3 Laboratory)

 Retro-orbital bleeding, bleeding from the ear lobe and immunization of animals (Mice, Rat, Guinea Pigs and Rabbit) for the generation of polyclonal antibodies etc. Infection of mice with Mycobacterium tuberculosis, Mycobacterium. microti etc

  Tissue culture Related:

 Maintenance of different mammalian cell lines (EL-4, WEHI-279, THP-1, HuT-78, JM-1, J774A.1, Jurkat, COS-7 etc.), experience of handling BALB/c, C57BL/6, C3He mice for isolation of peritoneal macrophages, splenocytes, Dendritic cells etc. Purification of naïve T cells and B cells by density gradient centrifugation, purification of dendritic cells from spleen and bone marrow, preparation of Baby rabbit complement, purification of monoclonal antibody from culture supernatant by using sepharose protein A and G columns and other cellular immunological techniques.

  Instruments conversant with:

 Flow-cytometer, Fluorescence microscope, Phosphor-Imager, Confocal microscope, Gel-doc, beta counter, Inverted microscope, Flourimeter and Luminometer, ELISA reader, Spectrophotometer, Sonicator, Centrifuges (RC5C, RC3C, table-top) etc.

Expertise in FACS

 Acquisition and analysis: Immuno-fluorescence staining of cell surface molecules (Two colour as well as Multi-colour) and intracellular staining of cytokines, expertise in Cell Quest and FACS PRO-Software’s of FACS acquisition and Analysis, Detection of apoptosis by PI staining.