Assistant Professor

(DST Inspire Faculty)

My research interests are focused mainly on understanding the basic biology, drug resistance, and regulation of membrane protein levels by various post-translational events in human pathogenic fungi, mostly belonging to the genus Candida. We also try to understand the drug resistance mechanisms adopted by different local clinical isolates of human pathogenic fungi. Besides research, I regularly teach various courses to Master’s level students at the University of Kashmir, Srinagar. In addition to research and teaching at university, I also serve as the American Society for Microbiology (ASM) Young Ambassador to India, wherein we try to advance the knowledge about microbial sciences locally.

Faculty Details

  • Citations 843
  • HIndex 12
  • i10 Index 18
  • Mobile 9596528258
  • Email abdulhaseeb@kashmiruniversity.ac.in
  • Resume View



Research Papers Published

  • "MFS transporters of Candida species and their role in clinical drug resistance" FEMS Yeast Res., 16(6): DOI No. 10.1093/femsyr/fow043 Impact Factor=
  • "Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric." Sci Rep., 6(30221): DOI No. 10.1038/srep30221 Impact Factor=
  • "Resistance to antifungal therapies" Essays in Biochemistry, 61(1): 157 -166 Impact Factor= 3
  • "Novel role of a family of major facilitator transporters in biofilm development and virulence of Candida albicans." Biochemical Journal, 460(2): 223 -235 Impact Factor= 4
  • "ABC transporter Cdr1p harbors charged residues in the intracellular loop and nucleotide-binding domain critical for protein trafficking and drug resistance." FEMS Yeast Research, 15(5): DOI No. 10.1093/femsyr/fov036 Impact Factor= 3.3
  • "In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2." Antimicrob Agents Chemother, 56(1): 495 -506 Impact Factor= 4
  • "Alanine scanning of all cysteines and construction of a functional cysteine-less Cdr1p, a multidrug ABC transporter of Candida albicans" BBRC, 417(1): 508 -513 Impact Factor= 2.5
  • "W1038 near D-loop of NBD2 is a focal point for inter-domain communication in multidrug transporter Cdr1 of Candida albicans." BBA-BIOMEMBRANES, 1860(5): 865 -872 {ISSN: 0005-2736,} Impact Factor= 3.5
  • "Quorum sensing: A less known mode of communication among fungi." Microbiological Research, 210(0): 51 -58 {ISSN: 0944-5013} Impact Factor= 3
  • "Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H+ Antiporter." Journal Of Molecular Biology, 430(5): 682 -692 {ISSN: 0022-2836} Impact Factor= 4.3
  • "Identification of Genomewide Alternative Splicing Events in Sequential, Isogenic Clinical Isolates of Candida albicans Reveals a Novel Mechanism of Drug Resistance and Tolerance to Cellular Stresses" mSphere, 5(4): DOI No. 10.1128/mSphere.00608-20 {ISSN: 2379-5042} Impact Factor= 4.28
  • "Glucose-The X Factor for the survival of human fungal pathogens and disease progression in the host" Microbiological Research, 247(126725): DOI No. 10.1016/j.micres.2021.126725 {ISSN: 0944-5013} Impact Factor= 3.9
  • "Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes" Curr Drug Targets, 22(11): 1 -13 Impact Factor= 2.6
  • "Metabolic flexibility and extensive adaptability governing multiple drug resistance and enhanced virulence in Candida albicans" Critical Reviews in Microbiology, 1(1): 1 -20 Impact Factor= 7.92
  • "Glucose - The X factor for the survival of human fungal pathogens and disease progression in the host." Microbiological Research, 247(00): DOI No. 10.1016/j.micres.2021.126725 Impact Factor= 5.4
  • "Quinidine drug resistance transporter knockout Candida cells modulate glucose transporter expression and accumulate metabolites leading to enhanced azole drug resistance" Fungal Genetics and Biology, 161(103713): DOI No. doi.org/10.1016/j.fgb.2022.103 Impact Factor= 3.88
  • "ß-Nitrostyrene derivatives as broad range potential antifungal agents targeting fungal cell wall" European Journal of Medicinal Chemistry, 240(114609): DOI No. doi.org/10.1016/j.ejmech.2022 Impact Factor= 7.08
  • "Glucose metabolic reprogramming and modulation in glycerol biosynthesis regulates drug resistance in clinical isolates of Candida" Journal of Appied Microbiology, 134(lxad091): DOI No. 10.1093/jambio/lxad091 {ISSN: 1364-5072} Impact Factor= 4.05
  • "Physicochemical and Anti-fungal Studies of the Pharmaceutical Co-crystal/Salt of Fluconazole" ACS Molecular Pharmaceutics, https://d(https://d): DOI No. 10.1021/acs.molpharmaceut.3c00 {ISSN: 1543-8384} Impact Factor= 5.36
  • "Dual Antifungal and Antiproliferative Activities of a Novel Protein Fraction from a Medicinally Important Herb Trillium govanianum Wall. ex. D. Don." Applied Biochemistry and Biotechnology, https://d(https://d): DOI No. doi.org/10.1007/s12010 {ISSN: 0273-2289} Impact Factor= 3.09

Books Published

  • "Antifungals: Mechanism of Action and Drug Resistance". Springer International Publishing Switzerland. {ISBN: 978-3-319-25302-2} pp 22
  • "Candida Efflux ATPases and Antiporters in Clinical Drug Resistance". Springer International Publishing Switzerland. {ISBN: 978-3-319-25302-2} pp 24
  • "Tools and Techniques to Study Multidrug Transporters of Yeasts". Springer International Publishing AG 2017. {ISBN: 978-3-319-49195-0} pp 24
  • "Mechanisms of Drug Resistance in Fungi and Their Significance in Biofilms". Springer-Verlag Berlin Heidelberg. {ISBN: 978-3-642-53832-2} pp 22
  • "Role of immunogenetics polymorphisms in infectious diseases". Academic Press. {ISBN: 978-0-323-90053-9} pp 22
  • "Combating human fungal infections: Need for new antifungal drugs and therapies". Elsevier Science Publishers USA. {ISBN: 9780323961271} pp 25

Research Projects Details:

Title of the ProjectFunding AgencyDatedAmount (in Rs.)
Drug resistance in fungi and the role of post translational modifications of membrane proteinsDST28-10-20153,500,000.00
Clinical drug resistant strains of pathogenic Candida: Elucidation of possible mechanism of drug resistance and drug toleranceSERB04-11-20164,154,768.00
Drug resistance in fungi and the role of post translational modifications of membrane proteinsDST28-10-20153,500,000.00
Clinical drug resistant strains of pathogenic Candida: Elucidation of possible mechanism of drug resistance and drug toleranceSERB04-11-20164,154,768.00
Drug resistance in fungi and the .... PTM of membrane proteinsDST28-10-20153,500,000.00
Clinical drug resistant strains of .... drug resistance and drug toleranceSERB04-11-20164,200,000.00
Drug resistance in fungi and the .... PTM of membrane proteinsDST25-07-20193,500,000.00
Clinical drug resistant strains of .... drug resistance and drug toleranceSERB03-02-20204,200,000.00
Drug resistance in fungi... PTM of membrane proteinsDST11-06-20203,500,000.00

Research Scholars:

NameCourseStatusNature
Sajad Ahmad PadderPh.D Awarded Whole Time
Asiya RamzanPh.D Awarded Whole Time

Teaching:

DepartmentSubjectCourse TaughtSemester
Bio-ResourcesM. Sc BioresourcesCell and Mol. Bio.1
Bio-ResourcesM. Sc BioresourcesInheritance Biology2
Bio-ResourcesM. Sc BioresourcesAnimal Resource Regeneration2
Bio-ResourcesM. Sc BioresourcesMicrobial Resources2
Bio-ResourcesM. Sc BioresourcesInheritance Biology2
Bio-ResourcesM. Sc BioresourcesAnimal Resource Regeneration2
Bio-ResourcesM. Sc BioresourcesMicrobial Resources2
Bio-ResourcesM. Sc BioresourcesBiostatistics and Biotechniques3
Bio-ResourcesM. Sc BioresourcesBiological Interactions3
Bio-ResourcesM. Sc BioresourcesCell and Mol. Immunology3
Bio-ResourcesM. Sc BioresourcesMicrobial Technology4
Bio-ResourcesM. Sc BioresourcesBioinformatics4
Bio-ResourcesM. Sc BioresourcesMicrobial Technology4
Bio-ResourcesM. Sc BioresourcesBioinformatics4
Bio-ResourcesM. Sc BioresourcesProject Work4